Discovery of tricyclic 5,6-dihydro-1H-pyridin-2-ones as novel, potent, and orally bioavailable inhibitors of HCV NS5B polymerase-Reference-Cited by-同舟云学术

Discovery of tricyclic 5,6-dihydro-1H-pyridin-2-ones as novel, potent, and orally bioavailable inhibitors of HCV NS5B polymerase

Published:2009-11 Issue:22 Volume:19 Page:6404-6412
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Ruebsam Frank,Murphy Douglas E.,Tran Chinh V.,Li Lian-Sheng,Zhao Jingjing,Dragovich Peter S.,McGuire Helen M.,Xiang Alan X.,Sun Zhongxiang,Ayida Benjamin K.,Blazel Julie K.,Kim Sun Hee,Zhou Yuefen,Han Qing,Kissinger Charles R.,Webber Stephen E.,Showalter Richard E.,Shah Amit M.,Tsan Mei,Patel Rupal A.,Thompson Peggy A.,LeBrun Laurie A.,Hou Huiying J.,Kamran Ruhi,Sergeeva Maria V.,Bartkowski Darian M.,Nolan Thomas G.,Norris Daniel A.,Khandurina Julia,Brooks Jennifer,Okamoto Ellen,Kirkovsky Leo

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference55 articles.

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2. CDC Hepatitis Fact Sheet, March 6, 2008, www.cdc.gov/hepatitis.

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4. Hepatitis C and liver transplantation

5. Broad-Spectrum Antiviral Activity of Virazole: 1-β-D-Ribofuranosyl-1,2,4-triazole-3-carboxamide

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