Trifluoromethylpyrimidine-based inhibitors of proline-rich tyrosine kinase 2 (PYK2): Structure–activity relationships and strategies for the elimination of reactive metabolite formation-Reference-Cited by-同舟云学术

Trifluoromethylpyrimidine-based inhibitors of proline-rich tyrosine kinase 2 (PYK2): Structure–activity relationships and strategies for the elimination of reactive metabolite formation

Published:2008-12 Issue:23 Volume:18 Page:6071-6077
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Walker Daniel P.,Christopher Bi F.,Kalgutkar Amit S.,Bauman Jonathan N.,Zhao Sabrina X.,Soglia John R.,Aspnes Gary E.,Kung Daniel W.,Klug-McLeod Jacquelyn,Zawistoski Michael P.,McGlynn Molly A.,Oliver Robert,Dunn Matthew,Li Jian-Cheng,Richter Daniel T.,Cooper Beth A.,Kath John C.,Hulford Catherine A.,Autry Christopher L.,Luzzio Michael J.,Ung Ethan J.,Roberts W. Gregory,Bonnette Peter C.,Buckbinder Leonard,Mistry Anil,Griffor Matthew C.,Han Seungil,Guzman-Perez Angel

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference18 articles.

1. Signaling through focal adhesion kinase

2. Absence of marginal zone B cells in Pyk-2–deficient mice defines their role in the humoral response

3. Pyk2 regulates multiple signaling events crucial for macrophage morphology and migration

4. Proline-rich tyrosine kinase 2 regulates osteoprogenitor cells and bone formation, and offers an anabolic treatment approach for osteoporosis

5. A Comprehensive Listing of Bioactivation Pathways of Organic Functional Groups

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