Synthesis of 5-(1-H or 1-alkyl-5-oxopyrrolidin-3-yl)-8-hydroxy-[1,6]-naphthyridine-7-carboxamide inhibitors of HIV-1 integrase-Reference-Cited by-同舟云学术

Synthesis of 5-(1-H or 1-alkyl-5-oxopyrrolidin-3-yl)-8-hydroxy-[1,6]-naphthyridine-7-carboxamide inhibitors of HIV-1 integrase

Published:2008-10 Issue:19 Volume:18 Page:5307-5310
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Melamed Jeffrey Y.,Egbertson Melissa S.,Varga Sandor,Vacca Joseph P.,Moyer Greg,Gabryelski Lori,Felock Peter J.,Stillmock Kara A.,Witmer Marc V.,Schleif William,Hazuda Daria J.,Leonard Yvonne,Jin Lixia,Ellis Joan D.,Young Steven D.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference11 articles.

1. Quinolone 3-Carboxylic Acid Pharmacophore: Design of Second Generation HIV-1 Integrase Inhibitors

2. Integrase inhibitors to treat HIV/Aids

3. Inhibitors of Strand Transfer That Prevent Integration and Inhibit HIV-1 Replication in Cells

4. Antiretroviral Activity, Pharmacokinetics, and Tolerability of MK-0518, a Novel Inhibitor of HIV-1 Integrase, Dosed As Monotherapy for 10 Days in Treatment-Naive HIV-1-Infected Individuals

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