Discovery of molecular switches within the ADX-47273 mGlu5 PAM scaffold that modulate modes of pharmacology to afford potent mGlu5 NAMs, PAMs and partial antagonists-Reference-Cited by-同舟云学术

Discovery of molecular switches within the ADX-47273 mGlu5 PAM scaffold that modulate modes of pharmacology to afford potent mGlu5 NAMs, PAMs and partial antagonists

Published:2011-05 Issue:9 Volume:21 Page:2711-2714
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Lamb Jeffrey P.,Engers Darren W.,Niswender Colleen M.,Rodriguez Alice L.,Venable Daryl F.,Conn P. Jeffrey,Lindsley Craig W.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference19 articles.

1. Pharmacological agents acting at subtypes of metabotropic glutamate receptors

2. PHARMACOLOGY AND FUNCTIONS OF METABOTROPIC GLUTAMATE RECEPTORS

3. Metabotropic Glutamate Receptor Subtype 5 Antagonists MPEP and MTEP

4. Positive and negative allosteric modulation of metabotropic glutamate receptors: emerging therapeutic potential

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