Identification of Novel Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5 Acting at Site Distinct from 2-Methyl-6-(phenylethynyl)-pyridine Binding-Reference-Cited by-同舟云学术

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Identification of Novel Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5 Acting at Site Distinct from 2-Methyl-6-(phenylethynyl)-pyridine Binding

Published:2019-05-27 Issue:8 Volume:10 Page:3427-3436
ISSN:1948-7193
Container-title:ACS Chemical Neuroscience
language:en
Short-container-title:ACS Chem. Neurosci.

Author:

Butkiewicz Mariusz^ORCID,Rodriguez Alice L.,Rainey Shane E.,Wieting Joshua,Luscombe Vincent B.,Stauffer Shaun R.,Lindsley Craig W.^ORCID,Conn P. Jeffrey,Meiler Jens

Funder

Efficacy and Mechanism Evaluation Programme

National Sleep Foundation

National Institutes of Health

Publisher

American Chemical Society (ACS)

Subject

Cell Biology,Cognitive Neuroscience,Physiology,Biochemistry,General Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acschemneuro.8b00227

Reference50 articles.

1. PHARMACOLOGY AND FUNCTIONS OF METABOTROPIC GLUTAMATE RECEPTORS

2. Pharmacological agents acting at subtypes of metabotropic glutamate receptors

3. Molecular characterization of a novel metabotropic glutamate receptor mGluR5 coupled to inositol phosphate/Ca2+ signal transduction.

4. Development of allosteric modulators of GPCRs for treatment of CNS disorders

5. Modulation of the Basal Ganglia by Metabotropic Glutamate Receptors: Potential for Novel Therapeutics

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