Optimization of α-ketoamide based p38 inhibitors through modifications to the region that binds to the allosteric site-Reference-Cited by-同舟云学术

Optimization of α-ketoamide based p38 inhibitors through modifications to the region that binds to the allosteric site

Published:2010-08 Issue:16 Volume:20 Page:4819-4824
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Montalban Antonio Garrido,Boman Erik,Chang Chau-Dung,Ceide Susana Conde,Dahl Russell,Dalesandro David,Delaet Nancy G.J.,Erb Eric,Ernst Justin T.,Gibbs Andrew,Kahl Jeffrey,Kessler Linda,Kucharski Jeff,Lum Christopher,Lundström Jan,Miller Stephen,Nakanishi Hiroshi,Roberts Edward,Saiah Eddine,Sullivan Robert,Urban Jan,Wang Zhijun,Larson Christopher J.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference26 articles.

1. 1-Substituted 4-Aryl-5-pyridinylimidazoles: A New Class of Cytokine Suppressive Drugs with Low 5-Lipoxygenase and Cyclooxygenase Inhibitory Potency

2. Pyrazole Urea-Based Inhibitors of p38 MAP Kinase: From Lead Compound to Clinical Candidate

3. Discovery and characterization of the N-phenyl-N′-naphthylurea class of p38 kinase inhibitors

4. Structural Comparison of p38 Inhibitor-Protein Complexes: A Review of Recent p38 Inhibitors Having Unique Binding Interactions

5. Etanercept

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