New Ag(I)−NHC/TBHP System for Oxidative Coupling of α‐Hydroxy Acetophenones with Amines: A Base‐Free and Efficient Synthesis of α‐Ketoamides in Water-Reference-Cited by-同舟云学术

New Ag(I)−NHC/TBHP System for Oxidative Coupling of α‐Hydroxy Acetophenones with Amines: A Base‐Free and Efficient Synthesis of α‐Ketoamides in Water

Published:2023-08-29 Issue:10 Volume:12 Page:
ISSN:2193-5807
Container-title:Asian Journal of Organic Chemistry
language:en
Short-container-title:Asian J Org Chem

Author:

Muqeed Mohammad¹,Manchal Ravinder¹,Botla Vinayak²,Azam Mohammad³,Vasam Chandra Sekhar⁴,Thirukovela Narasimha Swamy¹^ORCID

Affiliation:

1. Department of Chemistry Chaitanya Deemed to be University Warangal 506001 Telangana India

2. Department of Chemistry & Biochemistry University of Texas at Dallas TX 75080 Dallas United States

3. Department of Chemistry College of Science King Saud University PO Box 2455 Riyadh 11451 Saudi Arabia

4. Department of Pharmaceutical Chemistry Telangana University Nizamabad 503322 India

Abstract

AbstractA base‐free and efficient tandem one‐pot α‐ketoamide bond formation via tert‐butyl hydroperoxide (TBHP) mediated oxidative coupling of α‐hydroxy acetophenones with primary and secondary amines under Ag(I)‐N‐Heterocyclic carbene (Ag(I)−NHC) catalysis in water was developed herein for the first time.

Funder

King Saud University

Publisher

Wiley

Subject

Organic Chemistry

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/ajoc.202300356

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