Discovery of potent and liver-targeted stearoyl-CoA desaturase (SCD) inhibitors in a bispyrrolidine series-Reference-Cited by-同舟云学术

Discovery of potent and liver-targeted stearoyl-CoA desaturase (SCD) inhibitors in a bispyrrolidine series

Published:2012-01 Issue:2 Volume:22 Page:980-984
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Lachance Nicolas,Gareau Yves,Guiral Sébastien,Huang Zheng,Isabel Elise,Leclerc Jean-Philippe,Léger Serge,Martins Evelyn,Nadeau Christian,Oballa Renata M.,Ouellet Stéphane G.,Powell David A.,Ramtohul Yeeman K.,Tranmer Geoffrey K.,Trinh Thao,Wang Hao,Zhang Lei

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference24 articles.

1. Novel substituted heteroaromatic compounds as inhibitors of stearoyl-CoA desaturase

2. Stearoyl-CoA desaturase inhibitors: update on patented compounds

3. Synthesis and biological activity of a potent and orally bioavailable SCD inhibitor (MF-438)

4. SAR and optimization of thiazole analogs as potent stearoyl-CoA desaturase inhibitors

5. Thiazole analog as stearoyl-CoA desaturase 1 inhibitor

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