Synthesis and biological activity of a potent and orally bioavailable SCD inhibitor (MF-438)-Reference-Cited by-同舟云学术

Synthesis and biological activity of a potent and orally bioavailable SCD inhibitor (MF-438)

Published:2010-01 Issue:2 Volume:20 Page:499-502
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Léger Serge,Black W. Cameron,Deschenes Denis,Dolman Sarah,Falgueyret Jean-Pierre,Gagnon Marc,Guiral Sébastien,Huang Zheng,Guay Jocelyne,Leblanc Yves,Li Chun-Sing,Massé Frédéric,Oballa Renata,Zhang Lei

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference21 articles.

1. Eight Histidine Residues Are Catalytically Essential in a Membrane-Associated Iron Enzyme, Stearoyl-CoA Desaturase, and Are Conserved in Alkane Hydroxylase and Xylene Monooxygenase

2. Characterization of HSCD5, a novel human stearoyl-CoA desaturase unique to primates

3. Prevention of obesity in mice by antisense oligonucleotide inhibitors of stearoyl-CoA desaturase–1

4. Hepatic Stearoyl-CoA Desaturase-1 Deficiency Protects Mice from Carbohydrate-Induced Adiposity and Hepatic Steatosis

5. Dyslipidemia and Atherosclerosis Induced by Chronic Intermittent Hypoxia Are Attenuated by Deficiency of Stearoyl Coenzyme A Desaturase

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