Discovery of a novel chemotype of potent human ENaC blockers using a bioisostere approach. Part 1: Quaternary amines-Reference-Cited by-同舟云学术

Discovery of a novel chemotype of potent human ENaC blockers using a bioisostere approach. Part 1: Quaternary amines

Published:2012-01 Issue:2 Volume:22 Page:929-932
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Hunt Thomas,Atherton-Watson Hazel C.,Axford Jake,Collingwood Stephen P.,Coote Kevin J.,Cox Brian,Czarnecki Sarah,Danahay Henry,Devereux Nick,Howsham Catherine,Hunt Peter,Paddock Victoria,Paisley Derek,Young Alice

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference24 articles.

1. Epithelial sodium channels: function, structure, and regulation

2. Insight toward epithelial Na+channel mechanism revealed by the acid-sensing ion channel 1 structure

3. Determination of Epithelial Na+ Channel Subunit Stoichiometry from Single-Channel Conductances

4. Evidence for airway surface dehydration as the initiating event in CF airway disease

5. Regulation of airway mucosal hydration

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