Discovery of potent iminoheterocycle BACE1 inhibitors-Reference-Cited by-同舟云学术

Discovery of potent iminoheterocycle BACE1 inhibitors

Published:2014-12 Issue:23 Volume:24 Page:5455-5459
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Caldwell John P.,Mazzola Robert D.,Durkin James,Chen Joseph,Chen Xia,Favreau Leonard,Kennedy Matthew,Kuvelkar Reshma,Lee Julie,McHugh Nansie,McKittrick Brian,Orth Peter,Stamford Andrew,Strickland Corey,Voigt Johannes,Wang Liyang,Zhang Lili,Zhang Qi,Zhu Zhaoning

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference21 articles.

1. The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics

2. Application of Fragment-Based NMR Screening, X-ray Crystallography, Structure-Based Design, and Focused Chemical Library Design to Identify Novel μM Leads for the Development of nM BACE-1 (β-Site APP Cleaving Enzyme 1) Inhibitors

3. Discovery of Cyclic Acylguanidines as Highly Potent and Selective β-Site Amyloid Cleaving Enzyme (BACE) Inhibitors: Part I—Inhibitor Design and Validation

4. Structure based design of iminohydantoin BACE1 inhibitors: Identification of an orally available, centrally active BACE1 inhibitor

5. Discovery of an Orally Available, Brain Penetrant BACE1 Inhibitor That Affords Robust CNS Aβ Reduction

Cited by 17 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Rare ring conformations in PDB: Facts or wishful thinking?;2024-06-24

2. Enantioselective synthesis of spiroimidazolones by synergistic catalysis;Catalysis Today;2024-02

3. Nickel‐Catalyzed Stereoselective Migratory Carboboration of 1,4‐Cyclohexadiene^†;Chinese Journal of Chemistry;2023-11-06

4. Alzheimer Hastalığı ve Anti-Alzheimer Etkili Bileşiklerin Yapılarının Araştırılması;Hacettepe University Journal of the Faculty of Pharmacy;2023-05-08

5. Enantioselective Synthesis of Spiroimidazolones by Synergistic Catalysis;2023