Discovery of Cyclic Acylguanidines as Highly Potent and Selective β-Site Amyloid Cleaving Enzyme (BACE) Inhibitors: Part I—Inhibitor Design and Validation-Reference-Cited by-同舟云学术

Discovery of Cyclic Acylguanidines as Highly Potent and Selective β-Site Amyloid Cleaving Enzyme (BACE) Inhibitors: Part I—Inhibitor Design and Validation

Published:2009-12-31 Issue:3 Volume:53 Page:951-965
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Zhu Zhaoning¹,Sun Zhong-Yue¹,Ye Yuanzan¹,Voigt Johannes²,Strickland Corey²,Smith Elizabeth M.¹,Cumming Jared¹,Wang Lingyan¹,Wong Jesse¹,Wang Yu-Sen²,Wyss Daniel F.²,Chen Xia³,Kuvelkar Reshma³,Kennedy Matthew E.³,Favreau Leonard¹,Parker Eric³,McKittrick Brian A.¹,Stamford Andrew¹,Czarniecki Michael¹,Greenlee William¹,Hunter John C.³

Affiliation:

1. Department of Medicinal Chemistry

2. Department of Structural Chemistry

3. Department of Neurobiology

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm901408p

Reference85 articles.

1. Part of this work was first disclosed in the following patent:Zhu, Z.; McKittrick, B.; Sun, Z.Y.; Ye,Y.; Voigt, J.; Strickland, C.; Smith, E.; Stamford, A.; Greenlee, W.; Wu, Y.; Iserloh, U.; Mazzola, R.; Caldwell, J.; Cumming, J.; Wang, L.; Guo, T.; Le, T. X. H.; Saionz, K. W.; Babu, S. D.; Hunter, R. C.Preparation of heterocyclic aspartyl protease inhibitors for treating various diseases. Patent WO200505831, 2005.

2. A Familial Alzheimer's Disease Locus on Chromosome 1

3. Therapies for Alzheimer's disease

4. Costs to Society of Family Caregiving for Patients with End-Stage Alzheimer's Disease

5. Alzheimer disease: progress or profit?

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