Discovery of novel hydroxy-thiazoles as HIF-α prolyl hydroxylase inhibitors: SAR, synthesis, and modeling evaluation-Reference-Cited by-同舟云学术

Discovery of novel hydroxy-thiazoles as HIF-α prolyl hydroxylase inhibitors: SAR, synthesis, and modeling evaluation

Published:2008-07 Issue:14 Volume:18 Page:3925-3928
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Tegley Christopher M.,Viswanadhan Vellarkad N.,Biswas Kaustav,Frohn Michael J.,Peterkin Tanya A.N.,Chang Catherine,Bürli Roland W.,Dao Jennifer H.,Veith Henrike,Rogers Norma,Yoder Sean C.,Biddlecome Gloria,Tagari Philip,Allen Jennifer R.,Hungate Randall W.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference24 articles.

1. Oxygen sensing in the hypoxic response pathway: regulation of the hypoxia-inducible transcription factor

2. HIF hydroxylation and the mammalian oxygen-sensing pathway

3. Hydroxylation of HIF-1: Oxygen Sensing at the Molecular Level

4. Oxygen sensing by HIF hydroxylases

5. Regulation of angiogenesis by hypoxia: role of the HIF system

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