Design, synthesis, and evaluation of (2 S ,4 R )-Ketoconazole sulfonamide analogs as potential treatments for Metabolic Syndrome-Reference-Cited by-同舟云学术

Design, synthesis, and evaluation of (2 S ,4 R )-Ketoconazole sulfonamide analogs as potential treatments for Metabolic Syndrome

Published:2016-12 Issue:23 Volume:26 Page:5825-5829
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Blass Benjamin E.,Iyer Pravin,Abou-Gharbia Magid,Childers Wayne E.,Gordon John C.,Ramanjulu Mercy,Morton George,Arumugam Premkumar,Boruwa Joshodeep,Ellingboe John,Mitra Sayan,Nimmareddy Rajashekar Reddy,Paliwal Shalini,Rajasekhar Jamallamudi,Shivakumar Savithiri,Srivastava Pratima,Tangirala Raghuram S.,Venkataramanaiah Konda,Yanamandra Mahesh

Funder

Strongbridge Biopharma

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference26 articles.

1. Role of Insulin Resistance in Human Disease

2. The Pathogenetic Role of Cortisol in the Metabolic Syndrome: A Hypothesis

3. Glucocorticoids in type 2 diabetes mellitus and the metabolic syndrome

4. The Hypothalamic-Pituitary-Adrenal Axis Activity in Obesity and the Metabolic Syndrome

5. CYP17- and CYP11B-dependent steroid hydroxylases as drug development targets

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