Kinesin spindle protein (KSP) inhibitors. Part 7: Design and synthesis of 3,3-disubstituted dihydropyrazolobenzoxazines as potent inhibitors of the mitotic kinesin KSP-Reference-Cited by-同舟云学术

Kinesin spindle protein (KSP) inhibitors. Part 7: Design and synthesis of 3,3-disubstituted dihydropyrazolobenzoxazines as potent inhibitors of the mitotic kinesin KSP

Published:2007-10 Issue:20 Volume:17 Page:5671-5676
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Garbaccio Robert M.,Tasber Edward S.,Neilson Lou Anne,Coleman Paul J.,Fraley Mark E.,Olson Christy,Bergman Jeff,Torrent Maricel,Buser Carolyn A.,Rickert Keith,Walsh Eileen S.,Hamilton Kelly,Lobell Robert B.,Tao Weikang,South Vicki J.,Diehl Ronald E.,Davide Joseph P.,Yan Youwei,Kuo Lawrence C.,Li Chunze,Prueksaritanont Thomayant,Fernandez-Metzler Carmen,Mahan Elizabeth A.,Slaughter Donald E.,Salata Joseph J.,Kohl Nancy E.,Huber Hans E.,Hartman George D.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference8 articles.

1. Preceding communication.

2. Kinesin spindle protein (KSP) inhibitors. Part V: Discovery of 2-propylamino-2,4-diaryl-2,5-dihydropyrroles as potent, water-soluble KSP inhibitors, and modulation of their basicity by β-fluorination to overcome cellular efflux by P-glycoprotein

3. Intramolecular 1,3-dipolar cycloadditions of nitrile imines bearing an alkenyl substituent

4. An Alternative Procedure for the Aluminum-Mediated Conversion of Esters to Amides

5. N,N′-Dimethoxy-N,Nt́-Dimethylethanediamide: A Useful α-Oxo-N-Methoxy-N-Methylamide and 1,2-Diketone Synthon

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