Kinesin spindle protein (KSP) inhibitors. Part V: Discovery of 2-propylamino-2,4-diaryl-2,5-dihydropyrroles as potent, water-soluble KSP inhibitors, and modulation of their basicity by β-fluorination to overcome cellular efflux by P-glycoprotein-Reference-Cited by-同舟云学术

Kinesin spindle protein (KSP) inhibitors. Part V: Discovery of 2-propylamino-2,4-diaryl-2,5-dihydropyrroles as potent, water-soluble KSP inhibitors, and modulation of their basicity by β-fluorination to overcome cellular efflux by P-glycoprotein

Published:2007-05 Issue:10 Volume:17 Page:2697-2702
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Cox Christopher D.,Breslin Michael J.,Whitman David B.,Coleman Paul J.,Garbaccio Robert M.,Fraley Mark E.,Zrada Matthew M.,Buser Carolyn A.,Walsh Eileen S.,Hamilton Kelly,Lobell Robert B.,Tao Weikang,Abrams Marc T.,South Vicki J.,Huber Hans E.,Kohl Nancy E.,Hartman George D.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference31 articles.

1. Past and future of the mitotic spindle as an oncology target

2. 20th‐Century Advances in Drug Therapy in Oncology—Part I

3. Small Molecule Inhibitor of Mitotic Spindle Bipolarity Identified in a Phenotype-Based Screen

4. Antitumor Activity of a Kinesin Inhibitor

5. Mitotic Kinesin Inhibitors as Novel Anti-cancer Agents

Cited by 53 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Rhodium(III)-Catalyzed Intramolecular Cyclization and Sequential Aromatization of Ynamides with Propargyl Esters: Access to 2,5-Dihydropyrroles and Pyrroles;Organic Letters;2024-07-15

2. Model of P-Glycoprotein Ligand Binding and Validation with Efflux Substrate Matched Pairs;Journal of Medicinal Chemistry;2024-03-28

3. ATP‐Binding Cassette Transporters Mediated Chemoresistance in MCF-7 Cells: Modulation by PhTAD-Substituted Dihydropyrrole Compounds;Ahi Evran Medical Journal;2021-10-04

4. Synthesis of N-(2-SF5-ethyl)amines and impact of the SF5 substituent on their basicity and lipophilicity;Tetrahedron;2021-10

5. Evaluation of Prediction Accuracy for Volume of Distribution in Rat and Human Using In Vitro, In Vivo, PBPK and QSAR Methods;Journal of Pharmaceutical Sciences;2021-04