Model of P-Glycoprotein Ligand Binding and Validation with Efflux Substrate Matched Pairs-Reference-Cited by-同舟云学术

Model of P-Glycoprotein Ligand Binding and Validation with Efflux Substrate Matched Pairs

Published:2024-03-28 Issue:7 Volume:67 Page:5854-5865
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Conrad Jay¹²^ORCID,Paras Nick A.¹²^ORCID,Vaz Roy J.¹²

Affiliation:

1. Institute for Neurodegenerative Diseases, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, California 94158, United States

2. Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, California 94158, United States

Funder

Sherman Fairchild Foundation

Common Fund

Valour Foundation

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.4c00139

Reference27 articles.

1. P-Glycoprotein, a gatekeeper in the blood–brain barrier

2. Clinical Perspective of FDA Approved Drugs With P-Glycoprotein Inhibition Activities for Potential Cancer Therapeutics

3. Predicting Binding to P-Glycoprotein by Flexible Receptor Docking

4. Cryo-EM structures reveal distinct mechanisms of inhibition of the human multidrug transporter ABCB1

5. Structural insight into substrate and inhibitor discrimination by human P-glycoprotein

Cited by 1 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Design, synthesis, molecular modeling, in vitro and in vivo biological evaluation of potent anthranilamide derivatives as dual P-glycoprotein and CYP3A4 inhibitors;European Journal of Medicinal Chemistry;2024-07