Synthesis and SAR of 2-aryl pyrido[2,3-d]pyrimidines as potent mGlu5 receptor antagonists-Reference-Cited by-同舟云学术

Synthesis and SAR of 2-aryl pyrido[2,3-d]pyrimidines as potent mGlu5 receptor antagonists

Published:2007-10 Issue:19 Volume:17 Page:5396-5399
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Wendt John A.,Deeter Susan D.,Bove Susan E.,Knauer Christopher S.,Brooker Rachel M.,Augelli-Szafran Corinne E.,Schwarz Roy D.,Kinsora Jack J.,Kilgore Kenneth S.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference19 articles.

1. Metabotropic glutamate receptor 5 modulators and their potential therapeutic applications

2. Metabotropic glutamate receptors as novel targets for anxiety and stress disorders

3. 2-Methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist

4. The Non-competitive Antagonists 2-Methyl-6-(phenylethynyl)pyridine and 7-Hydroxyiminocyclopropan[b]chromen-1a-carboxylic Acid Ethyl Ester Interact with Overlapping Binding Pockets in the Transmembrane Region of Group I Metabotropic Glutamate Receptors

5. Chapter 3. Metabotropic glutamate receptors: Agonists, antagonists and allosteric modulators

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