Discovery of novel benzothiophene derivatives as potent and narrow spectrum inhibitors of DYRK1A and DYRK1B-Reference-Cited by-同舟云学术

Discovery of novel benzothiophene derivatives as potent and narrow spectrum inhibitors of DYRK1A and DYRK1B

Published:2022-07 Issue: Volume:68 Page:128764
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Segretti Natanael D.,Takarada Jéssica E.,Ferreira Marcos A.,da Silva Santiago André,Teodoro Bruno V.M.,Damião Mariana C.F.C.B.,Godoi Paulo H.,Cunha Micael R.,Fala Angela M.,Ramos Priscila Z.,Ishikawa Eloisa E.,Mascarello Alessandra,Serafim Ricardo A.M.,Azevedo Hatylas,Guimarães Cristiano R.W.,Couñago Rafael M.

Funder

Empresa Brasileira de Pesquisa e Inovação Industrial

Fundação de Amparo à Pesquisa do Estado de São Paulo

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference22 articles.

1. The Protein Kinase Complement of the Human Genome;Manning;Science,2002

2. DYRK1A: A Potential Drug Target for Multiple Down Syndrome Neuropathologies;Becker;CNS & Neurological Disorders – Drug Targets,2014

3. A High-Throughput Chemical Screen Reveals That Harmine-Mediated Inhibition of DYRK1A Increases Human Pancreatic Beta Cell Replication;Wang;Nat Med,2015

4. Inhibition of DYRK1A and GSK3B Induces Human β-Cell Proliferation. Nature;Shen;Communications,2015

5. Dyrk1A Induces Pancreatic β Cell Mass Expansion and Improves Glucose Tolerance;Rachdi;Cell Cycle,2014

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1. Identification of novel ureido benzothiophenes as dual VEGFR-2/EGFR anticancer agents;Bioorganic Chemistry;2024-02

2. Function and inhibition of DYRK1A: Emerging roles of treating multiple human diseases;Biochemical Pharmacology;2023-06

3. Isothiourea-catalysed enantioselective annulation of 2-aminobenzothiophenes with α,β-unsaturated anhydrides;Organic Chemistry Frontiers;2022