Novel pyrazolopyrimidines as highly potent B-Raf inhibitors-Reference-Cited by-同舟云学术

Novel pyrazolopyrimidines as highly potent B-Raf inhibitors

Published:2009-12 Issue:24 Volume:19 Page:6957-6961
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Di Grandi Martin J.,Berger Dan M.,Hopper Darrin W.,Zhang Chunchun,Dutia Minu,Dunnick Alejandro L.,Torres Nancy,Levin Jeremy I.,Diamantidis George,Zapf Christoph W.,Bloom Jonathan D.,Hu YongBo,Powell Dennis,Wojciechowicz Donald,Collins Karen,Frommer Eileen

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference14 articles.

1. Mechanism of Activation of the RAF-ERK Signaling Pathway by Oncogenic Mutations of B-RAF

2. Preclinical overview of sorafenib, a multikinase inhibitor that targets both Raf and VEGF and PDGF receptor tyrosine kinase signaling

3. Identification of pyrazolo[1,5-a]pyrimidine-3-carboxylates as B-Raf kinase inhibitors

4. Non-hinge-binding pyrazolo[1,5-a]pyrimidines as potent B-Raf kinase inhibitors

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