Discovery of pyrazol-3-ylamino pyrazines as novel JAK2 inhibitors-Reference-Cited by-同舟云学术

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Discovery of pyrazol-3-ylamino pyrazines as novel JAK2 inhibitors

Published:2009-12 Issue:23 Volume:19 Page:6524-6528
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Ioannidis Stephanos,Lamb Michelle L.,Davies Audrey M.,Almeida Lynsie,Su Mei,Bebernitz Geraldine,Ye Minwei,Bell Kirsten,Alimzhanov Marat,Zinda Michael

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference21 articles.

1. The Myeloproliferative Disorders

2. The Janus kinases (Jaks)

3. A new modality for immunosuppression: targeting the JAK/STAT pathway

4. A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera

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1. Pharmacophore-Based Virtual Screening and Experimental Validation of Pyrazolone-Derived Inhibitors toward Janus Kinases;ACS Omega;2022-09-06

2. Discovery of (2R)-N-[3-[2-[(3-Methoxy-1-methyl-pyrazol-4-yl)amino]pyrimidin-4-yl]-1H-indol-7-yl]-2-(4-methylpiperazin-1-yl)propenamide (AZD4205) as a Potent and Selective Janus Kinase 1 Inhibitor;Journal of Medicinal Chemistry;2020-04-16

3. Discovery of novel selective Janus kinase 2 (JAK2) inhibitors bearing a 1H-pyrazolo[3,4-d]pyrimidin-4-amino scaffold;Bioorganic & Medicinal Chemistry;2019-04

4. Molecular dynamics and integrated pharmacophore-based identification of dual $$\hbox {JAK3/PI3K}\delta $$ JAK3/PI3K δ inhibitors;Molecular Diversity;2017-11-14

5. A Synopsis of the Properties and Applications of Heteroaromatic Rings in Medicinal Chemistry;Advances in Heterocyclic Chemistry;2017

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