Discovery of (2R)-N-[3-[2-[(3-Methoxy-1-methyl-pyrazol-4-yl)amino]pyrimidin-4-yl]-1H-indol-7-yl]-2-(4-methylpiperazin-1-yl)propenamide (AZD4205) as a Potent and Selective Janus Kinase 1 Inhibitor-Reference-Cited by-同舟云学术

Discovery of (2R)-N-[3-[2-[(3-Methoxy-1-methyl-pyrazol-4-yl)amino]pyrimidin-4-yl]-1H-indol-7-yl]-2-(4-methylpiperazin-1-yl)propenamide (AZD4205) as a Potent and Selective Janus Kinase 1 Inhibitor

Published:2020-04-16 Issue:9 Volume:63 Page:4517-4527
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Su Qibin¹^ORCID,Banks Erica¹,Bebernitz Geraldine¹,Bell Kirsten¹,Borenstein Cassandra F.¹,Chen Huawei¹,Chuaqui Claudio E.¹,Deng Nanhua¹,Ferguson Andrew D.²^ORCID,Kawatkar Sameer¹,Grimster Neil P.¹^ORCID,Ruston Linette¹,Lyne Paul D.¹,Read Jon A.³,Peng Xianyou⁴,Pei Xiaohui⁴,Fawell Stephen¹,Tang Zhanlei⁴,Throner Scott¹,Vasbinder Melissa M.¹,Wang Haoyu⁴,Winter-Holt Jon⁵,Woessner Richard¹,Wu Allan²,Yang Wenzhan⁶,Zinda Michael¹,Kettle Jason G.⁵^ORCID

Affiliation:

1. Oncology R&D, AstraZeneca R&D, Waltham, Massachusetts 02451, United States

2. Discovery Sciences, R&D, AstraZeneca R&D, Waltham, Massachusetts 02451, United States

3. Discovery Sciences, R&D, AstraZeneca R&D, Cambridge CB4 0WG, U.K.

4. Pharmaron Beijing Co., Ltd., 6 Taihe Road, BDA, Beijing 100176, China

5. Oncology R&D, AstraZeneca R&D, Cambridge CB4 0WG, U.K.

6. Early Product Development, Pharmaceutical Sciences, R&D, Boston, Massachusetts 02451, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link