Optimization of a series of 2,4-diaminopyridines as neuropeptide Y Y1 receptor antagonists with reduced hERG activity-Reference-Cited by-同舟云学术

Optimization of a series of 2,4-diaminopyridines as neuropeptide Y Y1 receptor antagonists with reduced hERG activity

Published:2009-08 Issue:15 Volume:19 Page:4325-4329
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Kameda Minoru,Kobayashi Kensuke,Ito Hirokatsu,Miyazoe Hiroshi,Tsujino Toshiaki,Nakama Chisato,Kawamoto Hiroshi,Ando Makoto,Ito Sayaka,Suzuki Tomoki,Kanno Tetsuya,Tanaka Takeshi,Tahara Yoshio,Tani Takeshi,Tanaka Sachiko,Tokita Shigeru,Sato Nagaaki

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference25 articles.

1. Neuropeptide Y—a novel brain peptide with structural similarities to peptide YY and pancreatic polypeptide

2. Neuropeptide Y and peptide YY neuronal and endocrine systems

3. Synthesis of receptor antagonists of neuropeptide Y.

4. Neuropeptide Y injected in the paraventricular hypothalamus: a powerful stimulant of feeding behavior.

5. Evidence for neuropeptide Y mediation of eating produced by food deprivation and for a variant of the Y1 receptor mediating this peptide's effect

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3. Strategies To Reduce hERG K+Channel Blockade. Exploring Heteroaromaticity and Rigidity in Novel Pyridine Analogues of Dofetilide;Journal of Medicinal Chemistry;2013-03-29

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