Strategies To Reduce hERG K+Channel Blockade. Exploring Heteroaromaticity and Rigidity in Novel Pyridine Analogues of Dofetilide
Author:
Affiliation:
1. Leiden Academic Center for Drug Research, Leiden University, P.O. Box 9502, 2300 RA Leiden, The Netherlands
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/jm301564f
Reference40 articles.
1. Calibrated Measurement of Gating-Charge Arginine Displacement in the KvAP Voltage-Dependent K+ Channel
2. hERG potassium channels and cardiac arrhythmia
3. Safety and secondary pharmacology: Successes, threats, challenges and opportunities
4. Exploring Chemical Substructures Essential for hERG K+Channel Blockade by Synthesis and Biological Evaluation of Dofetilide Analogues
5. Understanding of Molecular Substructures that Contribute to hERG K+ Channel Blockade: Synthesis and Biological Evaluation of E-4031 Analogues
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