Identification of 2-substituted pyrrolo[1,2-b]pyridazine derivatives as new PARP-1 inhibitors-Reference-Cited by-同舟云学术

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Identification of 2-substituted pyrrolo[1,2-b]pyridazine derivatives as new PARP-1 inhibitors

Published:2021-01 Issue: Volume:31 Page:127710
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Xiang Hao-Yue,Chen Jian-Yang,Huan Xia-Juan,Chen Yi,Gao Zhao-bing,Ding Jian,Miao Ze-Hong,Yang Chun-Hao

Funder

Shanghai Institute of Materia Medica, Chinese Academy of Sciences

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference33 articles.

1. The roles of PARP1 in gene control and cell differentiation

2. Laying a trap to kill cancer cells: PARP inhibitors and their mechanisms of action

3. PARP inhibitors: Synthetic lethality in the clinic

4. Synthetic lethal therapies for cancer: what’s next after PARP inhibitors?

5. Structure and function of poly(ADP-ribose) polymerase

Cited by 15 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Recent contributions of pyridazine as a privileged scaffold of anticancer agents in medicinal chemistry: An updated review;Bioorganic & Medicinal Chemistry;2024-09

2. Poly (ADP-ribose) polymerase (PARP) inhibitors as anticancer agents: An outlook on clinical progress, synthetic strategies, biological activity, and structure-activity relationship;European Journal of Medicinal Chemistry;2024-08

3. Targeting selective inhibitors of PARPs in drug discovery and development;Medicinal Chemistry Research;2024-07-28

4. Design and synthesis of novel chloropyridazine hybrids as promising anticancer agents acting by apoptosis induction and PARP-1 inhibition through a molecular hybridization strategy;RSC Medicinal Chemistry;2024

5. Synthesis and Biological Evaluation of 12-Aryl-11-hydroxy-5,6-dihydropyrrolo[2″,1″:3′,4′]pyrazino[1′,2′:1,5]pyrrolo[2,3-d]pyridazine-8(9H)-one Derivatives as Potential Cytotoxic Agents;ACS Omega;2023-10-31

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