Synthesis of 2′-O,4′-C-alkylene-bridged ribonucleosides and their evaluation as inhibitors of HCV NS5B polymerase-Reference-Cited by-同舟云学术

Synthesis of 2′-O,4′-C-alkylene-bridged ribonucleosides and their evaluation as inhibitors of HCV NS5B polymerase

Published:2014-06 Issue:12 Volume:24 Page:2699-2702
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Chapron Christopher,Glen Rebecca,La Colla Massimiliano,Mayes Benjamin A.,McCarville Joseph F.,Moore Stephen,Moussa Adel,Sarkar Ruhul,Seifer Maria,Serra Ilaria,Stewart Alistair^ORCID

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference37 articles.

1. Synthesis of 2′-O,4′-C-methyleneuridine and -cytidine. Novel bicyclic nucleosides having a fixed C3, -endo sugar puckering

2. LNA (Locked Nucleic Acids): Synthesis of the adenine, cytosine, guanine, 5-methylcytosine, thymine and uracil bicyclonucleoside monomers, oligomerisation, and unprecedented nucleic acid recognition

3. Locked Nucleic Acids: Promising Nucleic Acid Analogs for Therapeutic Applications

4. Locked Nucleic Acid: A Potent Nucleic Acid Analog in Therapeutics and Biotechnology

5. Locked vs. unlocked nucleic acids (LNA vs. UNA): contrasting structures work towards common therapeutic goals

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1. Synthesis and Evaluation of Novel 5‐O‐(4‐C‐Aminoalkyl‐β‐D‐ribofuranosyl) Apramycin Derivatives for the Inhibition of Gram‐Negative Pathogens Carrying the Aminoglycoside Phosphotransferase(3′)‐Ia Resistance Determinant;Helvetica Chimica Acta;2023-10-09

2. Advances in the Synthesis and Antisense Technology Applications of Bridged Nucleic Acid Monomers;Current Organic Chemistry;2021-11-01

3. Chemical Synthesis and Biological Application of Modified Oligonucleotides;Bioconjugate Chemistry;2020-03-31

4. Synthesis of 6′‐Methyl‐2′‐ O ,4′‐ C ‐methylene‐ α ‐L‐ ribofuranosyl‐pyrimidine Nucleosides;ChemistrySelect;2019-03-20

5. Synthesis of novel C -4ʹ-spiro-oxetano- α -L- ribo nucleosides;Carbohydrate Research;2017-06