Design, synthesis, and evaluation of imidazo[4,5-c]pyridin-4-one derivatives with dual activity at angiotensin II type 1 receptor and peroxisome proliferator-activated receptor-γ-Reference-Cited by-同舟云学术

Design, synthesis, and evaluation of imidazo[4,5-c]pyridin-4-one derivatives with dual activity at angiotensin II type 1 receptor and peroxisome proliferator-activated receptor-γ

Published:2013-02 Issue:3 Volume:23 Page:767-772
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Casimiro-Garcia Agustin,Heemstra Ronald J.,Bigge Christopher F.,Chen Jing,Ciske Fred A.,Davis Jo Ann,Ellis Teresa,Esmaeil Nadia,Flynn Declan,Han Seungil,Jalaie Mehran,Ohren Jeffrey F.,Powell Noel A.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference20 articles.

1. Metabolic syndrome: Definition, pathophysiology, and mechanisms

2. Drug therapy of the metabolic syndrome: minimizing the emerging crisis in polypharmacy

3. Angiotensin Type 1 Receptor Blockers Induce Peroxisome Proliferator–Activated Receptor-γ Activity

4. Identification of Telmisartan as a Unique Angiotensin II Receptor Antagonist With Selective PPARγ–Modulating Activity

5. Effective treatment of hypertension by AT1receptor antagonism: the past and future of telmisartan

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