Discovery of a potent and highly selective PDK1 inhibitor via fragment-based drug discovery-Reference-Cited by-同舟云学术

Discovery of a potent and highly selective PDK1 inhibitor via fragment-based drug discovery

Published:2011-05 Issue:10 Volume:21 Page:3078-3083
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Erlanson Daniel A.,Arndt Joseph W.,Cancilla Mark T.,Cao Kathy,Elling Robert A.,English Nicki,Friedman Jessica,Hansen Stig K.,Hession Cathy,Joseph Ingrid,Kumaravel Gnanasambandam,Lee Wen-Cherng,Lind Ken E.,McDowell Robert S.,Miatkowski Konrad,Nguyen Christine,Nguyen Thinh B.,Park Sophia,Pathan Nuzhat,Penny David M.,Romanowski Michael J.,Scott Daniel,Silvian Laura,Simmons Robert L.,Tangonan Bradley T.,Yang Wenjin,Sun Lihong

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference20 articles.

1. PDK1, the master regulator of AGC kinase signal transduction

2. Novel Small Molecule Inhibitors of 3-Phosphoinositide-dependent Kinase-1

3. Discovery of Dibenzo[c,f][2,7]naphthyridines as Potent and Selective 3-Phosphoinositide-Dependent Kinase-1 Inhibitors

4. Indolinone based phosphoinositide-dependent kinase-1 (PDK1) inhibitors. Part 1: Design, synthesis and biological activity

5. Indolinone based phosphoinositide-dependent kinase-1 (PDK1) inhibitors. Part 2: Optimization of BX-517

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