Indolinone based phosphoinositide-dependent kinase-1 (PDK1) inhibitors. Part 2: Optimization of BX-517-Reference-Cited by-同舟云学术

Indolinone based phosphoinositide-dependent kinase-1 (PDK1) inhibitors. Part 2: Optimization of BX-517

Published:2007-07 Issue:14 Volume:17 Page:3819-3825
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Islam Imadul,Brown Greg,Bryant Judi,Hrvatin Paul,Kochanny Monica J.,Phillips Gary B.,Yuan Shendong,Adler Marc,Whitlow Marc,Lentz Dao,Polokoff Mark A.,Wu James,Shen Jun,Walters Janette,Ho Elena,Subramanyam Babu,Zhu Daguang,Feldman Richard I.,Arnaiz Damian O.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference13 articles.

1. PDK1, the master regulator of AGC kinase signal transduction

2. 3'-phosphoinositide-dependent kinase-1 (PDK-1) in PI 3-kinase signaling

3. Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα

4. The Akt Pathway: Molecular Targets for Anti-Cancer Drug Development

5. Structure, regulation and function of PKB/AKT—a major therapeutic target

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