Determination of the active stereoisomer of the MEP pathway-targeting antimalarial agent MMV008138, and initial structure–activity studies-Reference-Cited by-同舟云学术

Determination of the active stereoisomer of the MEP pathway-targeting antimalarial agent MMV008138, and initial structure–activity studies

Published:2015-04 Issue:7 Volume:25 Page:1515-1519
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Yao Zhong-Ke,Krai Priscilla M.,Merino Emilio F.,Simpson Morgan E.,Slebodnick Carla,Cassera Maria Belen,Carlier Paul R.

Funder

Fralin Life Science Institute

National Institutes of Health

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference21 articles.

1. World Malaria Report 2014, The World Health Organization, available at http://apps.who.int/iris/bitstream/10665/144852/2/9789241564830_eng.pdf, last accessed 12/17/14.

2. The apicoplast as an antimalarial drug target

3. Inhibitors of the Nonmevalonate Pathway of Isoprenoid Biosynthesis as Antimalarial Drugs

4. Development of Inhibitors of the 2C-Methyl-d-erythritol 4-Phosphate (MEP) Pathway Enzymes as Potential Anti-Infective Agents

5. Chemical Rescue of Malaria Parasites Lacking an Apicoplast Defines Organelle Function in Blood-Stage Plasmodium falciparum

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