Design and development of a series of borocycles as selective, covalent kallikrein 5 inhibitors-Reference-Cited by-同舟云学术

Design and development of a series of borocycles as selective, covalent kallikrein 5 inhibitors

Published:2019-10 Issue:20 Volume:29 Page:126675
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Walker Ann L.,Denis Alexis,Bingham Ryan P.,Bouillot Anne,Edgar Emma V.,Ferrie Alan,Holmes Duncan S.,Laroze Alain,Liddle John,Fouchet Marie-Helene,Moquette Alexandre,Nassau Pam,Pearce Andrew C.,Polyakova Oxana,Smith Kathrine J.,Thomas Pamela,Thorpe James H.,Trottet Lionel,Wang Yichen,Hovnanian Alain

Funder

GlaxoSmithKline

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference23 articles.

1. Netherton's disease; trichorrhexis invaginata (bamboo hair), congenital ichthyosiform erythroderma and the atopic diathesis. A histopathologic study;Wilkinson;Arch Dermatol,1964

2. Mutations in SPINK5, encoding a serine protease inhibitor, cause Netherton syndrome;Chavanas;Nat Genet,2000

3. LEKTI fragments specifically inhibit KLK5, KLK7, and KLK14 and control desquamation through a pH-dependent interaction;Deraison;Mol Biol Cell,2007

4. Kallikrein 5 induces atopic dermatitis-like lesions through PAR2-mediated thymic stromal lymphopoietin expression in Netherton syndrome;Briot;J Exp Med,2009

5. Unleashing the therapeutic potential of human kallikrein-related serine proteases;Prassas;Nat Rev Drug Discov,2015

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1. Emerging and Re-emerging Warheads for Targeted Covalent Inhibitors: An Update;Journal of Medicinal Chemistry;2024-05-07

2. Comparative analyses of Netherton syndrome patients and Spink5 conditional knock-out mice uncover disease-relevant pathways;Communications Biology;2024-02-05

3. A Potent and Selective Kallikrein-5 Inhibitor Delivers High Pharmacological Activity in Skin from Patients with Netherton Syndrome;Journal of Investigative Dermatology;2021-09

4. Advancing novel therapies for ichthyoses;British Journal of Dermatology;2020-12-30

5. Fragment-to-Lead Medicinal Chemistry Publications in 2019;Journal of Medicinal Chemistry;2020-11-23