A Potent and Selective Kallikrein-5 Inhibitor Delivers High Pharmacological Activity in Skin from Patients with Netherton Syndrome-Reference-Cited by-同舟云学术

A Potent and Selective Kallikrein-5 Inhibitor Delivers High Pharmacological Activity in Skin from Patients with Netherton Syndrome

Published:2021-09 Issue:9 Volume:141 Page:2272-2279
ISSN:0022-202X
Container-title:Journal of Investigative Dermatology
language:en
Short-container-title:Journal of Investigative Dermatology

Author:

Liddle John^ORCID,Beneton Veronique^ORCID,Benson Matthew^ORCID,Bingham Ryan^ORCID,Bouillot Anne^ORCID,Boullay Anne-Benedicte^ORCID,Brook Eloisa^ORCID,Cryan Jenni^ORCID,Denis Alexis^ORCID,Edgar Emma^ORCID,Ferrie Alan^ORCID,Fouchet Marie-Helene^ORCID,Grillot Didier^ORCID,Holmes Duncan S.^ORCID,Howes Ashleigh^ORCID,Krysa Gael^ORCID,Laroze Alain^ORCID,Lennon Mark^ORCID,McClure Fiona^ORCID,Moquette Alexandre^ORCID,Nicodeme Edwige^ORCID,Santiago Brandon^ORCID,Santos Leandro^ORCID,Smith Kathrine J.^ORCID,Thorpe James H.^ORCID,Thripp Gary^ORCID,Trottet Lionel^ORCID,Walker Ann L.^ORCID,Ward Simon A.^ORCID,Wang Yichen^ORCID,Wilson Steve^ORCID,Pearce Andrew C.^ORCID,Hovnanian Alain^ORCID

Funder

GlaxoSmithKline

Publisher

Elsevier BV

Subject

Cell Biology,Dermatology,Molecular Biology,Biochemistry

Reference46 articles.

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3. Elastase 2 is expressed in human and mouse epidermis and impairs skin barrier function in Netherton syndrome through filaggrin and lipid misprocessing;Bonnart;J Clin Invest,2010

4. Kallikrein 5 induces atopic dermatitis-like lesions through PAR2-mediated thymic stromal lymphopoietin expression in Netherton syndrome;Briot;J Exp Med,2009

5. Mutations in SPINK5, encoding a serine protease inhibitor, cause Netherton syndrome;Chavanas;Nat Genet,2000

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