Synthesis and biological evaluation of substituted benzoxazoles as inhibitors of mPGES-1: Use of a conformation-based hypothesis to facilitate compound design-Reference-Cited by-同舟云学术

Synthesis and biological evaluation of substituted benzoxazoles as inhibitors of mPGES-1: Use of a conformation-based hypothesis to facilitate compound design

Published:2013-02 Issue:4 Volume:23 Page:1120-1126
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Walker Daniel P.,Arhancet Graciela B.,Lu Hwang-Fun,Heasley Steven E.,Metz Sue,Kablaoui Natasha M.,Franco Francisco M.,Hanau Cathleen E.,Scholten Jeffrey A.,Springer John R.,Fobian Yvette M.,Carter Jeffrey S.,Xing Li,Yang Shengtian,Shaffer Alexander F.,Jerome Gina M.,Baratta Michael T.,Moore William M.,Vazquez Michael L.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference23 articles.

1. Inhibitors of the Microsomal Prostaglandin E2 Synthase-1 as Alternative to Non Steroidal Anti-Inflammatory Drugs (NSAIDs) – A Critical Review

2. Membrane Prostaglandin E Synthase-1: A Novel Therapeutic Target

3. Drug-like properties and the causes of poor solubility and poor permeability

4. L-735,524: The Design of a Potent and Orally Bioavailable HIV Protease Inhibitor

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