Discovery of a new isomannide-based peptidomimetic synthetized by Ugi multicomponent reaction as human tissue kallikrein 1 inhibitor

Author:

Barros Thalita G.,Santos Jorge A.N.,de Souza Bruno E.G.,Sodero Ana Carolina R.,de Souza Alessandra M.T.,da Silva Dayane P.,Rodrigues Carlos Rangel,Pinheiro Sergio,Dias Luiza R.S.,Abrahim-Vieira Bárbara,Puzer Luciano,Muri Estela M.F.

Funder

Coordination for the Improvement of Higher Education Personnel

National Council for Scientific and Technological Development

Carlos Chagas Filho Foundation for Support of Research of the State of Rio de Janeiro

Foundation for Support of Research of the State of São Paulo

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference19 articles.

1. The new human tissue kallikrein gene family: structure, function, and association to disease;Yousef;Endocr Rev,2001

2. Unleashing the therapeutic potential of human kallikrein-related serine proteases;Prassas;Nat Rev Drug Discov,2015

3. 1.70Å X-ray structure of human apokallikrein 1: structural changes upon peptide inhibitor/substrate binding;Laxmikanthan;Proteins: Struct Funct Bioinf,2005

4. The kallikrein-kinin system in diabetic retinopathy;Bhat;Prog Drug Res,2014

5. Isomannide derivatives as new class of inhibitors for human kallikrein 7;Freitas;Bioorg Med Chem Lett,2012

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