Multicomponent Reactions in the Last 30 Years: How are we Today?

Abstract

In this review, the works carried out in Brazil with multicomponent reactions over a period of 30 years were mapped through search in the literature (PubMed, Scopus, and Web of Science). A significant increase in papers with multicomponent reactions in Brazil was identified. In total, 243 articles with 6,672 citations (average of 27.46 citations per article) were found. Biginelli, Ugi, Mannich, Passerini and Hantzsch are the most employed reactions, and the articles were classified in medicinal chemistry, catalyst, mechanism, green chemistry, asymmetric synthesis and fluorescent. A bibliometric analysis with the 243 articles was performed, including the number of publications, citations, predominant journals, Brazilian universities with the highest number of publications on the subject, and international collaborations.