Acylguanidine inhibitors of β-secretase: Optimization of the pyrrole ring substituents extending into the S1 and S3 substrate binding pockets-Reference-Cited by-同舟云学术

Acylguanidine inhibitors of β-secretase: Optimization of the pyrrole ring substituents extending into the S1 and S3 substrate binding pockets

Published:2008-02 Issue:3 Volume:18 Page:1063-1066
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Cole Derek C.,Stock Joseph R.,Chopra Rajiv,Cowling Rebecca,Ellingboe John W.,Fan Kristi Y.,Harrison Boyd L.,Hu Yun,Jacobsen Steve,Jennings Lee D.,Jin Guixian,Lohse Peter A.,Malamas Michael S.,Manas Eric S.,Moore William J.,O’Donnell Mary-Margaret,Olland Andrea M.,Robichaud Albert J.,Svenson Kristine,Wu JunJun,Wagner Eric,Bard Jonathan

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

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4. Purification and cloning of amyloid precursor protein β-secretase from human brain

5. Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and γ-secretase activity

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