Photoactivated γ-secretase inhibitors directed to the active site covalently label presenilin 1-Reference-Cited by-同舟云学术

Photoactivated γ-secretase inhibitors directed to the active site covalently label presenilin 1

Published:2000-06 Issue:6787 Volume:405 Page:689-694
ISSN:0028-0836
Container-title:Nature
language:en
Short-container-title:Nature

Author:

Li Yue-Ming,Xu Min,Lai Ming-Tain,Huang Qian,Castro José L.,DiMuzio-Mower Jillian,Harrison Timothy,Lellis Colin,Nadin Alan,Neduvelil Joseph G.,Register R. Bruce,Sardana Mohinder K.,Shearman Mark S.,Smith Adrian L.,Shi Xiao-Ping,Yin Kuo-Chang,Shafer Jules A.,Gardell Stephen J.

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Link

http://www.nature.com/articles/35015085.pdf

Reference23 articles.

1. Selkoe, D. J. The cell biology of β-amyloid precursor protein and presenilin in Alzheimer's disease. Trends Cell Biol. 8, 447– 453 (1998).

2. Sherrington, R. et al. Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. Nature 375, 754–760 (1995).

3. Levy-Lahad, E. et al. A familial Alzheimer's disease locus on chromosome 1. Science 269, 970–973 ( 1995).

4. Scheuner, D. et al. Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease. Nature Med. 2, 864–870 ( 1996).

5. Duff, K. et al. Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1. Nature 383, 710– 713 (1996).

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