Synthesis of a novel tricyclic 1,2,3,4,4a,5,6,10b-octahydro-1,10-phenanthroline ring system and CXCR4 antagonists with potent activity against HIV-1-Reference-Cited by-同舟云学术

Synthesis of a novel tricyclic 1,2,3,4,4a,5,6,10b-octahydro-1,10-phenanthroline ring system and CXCR4 antagonists with potent activity against HIV-1

Published:2010-04 Issue:7 Volume:20 Page:2186-2190
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Catalano John G.,Gudmundsson Kristjan S.,Svolto Angilique,Boggs Sharon D.,Miller John F.,Spaltenstein Andrew,Thomson Michael,Wheelan Pat,Minick Doug J.,Phelps Dean P.,Jenkinson Stephen

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference22 articles.

1. A seven-transmembrane domain receptor involved in fusion and entry of T-cell-tropic human immunodeficiency virus type 1 strains

2. AMD3100: CXCR4 antagonist and rapid stem cell-mobilizing agent

3. Co-receptor antagonists as HIV-1 entry inhibitors

4. Enhanced Inhibition of Human Immunodeficiency Virus Type 1 by Met-Stromal-Derived Factor 1β Correlates with Down-Modulation of CXCR4

5. Solution structure and basis for functional activity of stromal cell-derived factor-1; dissociation of CXCR4 activation from binding and inhibition of HIV-1

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