Cyclopentane-based human NK1 antagonists. Part 1: Discovery and initial SAR-Reference-Cited by-同舟云学术

Cyclopentane-based human NK1 antagonists. Part 1: Discovery and initial SAR

Published:2006-09 Issue:17 Volume:16 Page:4497-4503
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Finke Paul E.,Meurer Laura C.,Levorse Dorothy A.,Mills Sander G.,MacCoss Malcolm,Sadowski Sharon,Cascieri Margaret A.,Tsao Kwei-Lan,Chicchi Gary G.,Metzger Joseph M.,MacIntyre D. Euan

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference27 articles.

1. The tachykinin NK1 receptor. Part II: Distribution and pathophysiological roles

2. Discovery of the antidepressant and anti-emetic efficacy of substance P receptor (NK1) antagonists

3. Aprepitant

4. Structural Optimization Affording 2-(R)-(1-(R)-3,5-Bis(trifluoromethyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (3-oxo-1,2,4-triazol-5-yl)methylmorpholine, a Potent, Orally Active, Long-Acting Morpholine Acetal Human NK-1 Receptor Antagonist

5. Aprepitant: An oral NK1 antagonist for the prevention of nausea and vomiting induced by highly emetogenic chemotherapy

Cited by 40 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. γ-CF₃-Allenamides versus 3-CF₃-Cyclopentenylamines: Substituent-Controlled Divergent Reaction of β-CF₃-1,3-Enynamides with β-Dicarbonyl Compounds;The Journal of Organic Chemistry;2024-09-10

2. Diastereoselective Hydrogenation of Tetrasubstituted Olefins using a Heterogeneous Pt‐Ni Alloy Catalyst;Angewandte Chemie International Edition;2024-03-28

3. Diastereoselective Hydrogenation of Tetrasubstituted Olefins using a Heterogeneous Pt‐Ni Alloy Catalyst;Angewandte Chemie;2024-03-13

4. Синтез и некоторые биологические свойства соединений, содержащих в молекуле два остатка 5-(4-гидроксибензилиден)-4-имидазолона;Chemical Journal of Armenia;2022-12-26

5. Synthesis and Anticholinesterase Activity of Some 2,5-Disubstituted Imidazol-4-ones Derived from the Green Fluorescent Protein Chromophore;Russian Journal of Organic Chemistry;2022-07