Discovery of (2S)-N-[(1R)-2-[4-cyclohexyl-4-[[(1,1-dimethylethyl)amino]carbonyl]-1-piperidinyl]-1-[(4-fluorophenyl)methyl]-2-oxoethyl]-4-methyl-2-piperazinecarboxamide (MB243), a potent and selective melanocortin subtype-4 receptor agonist-Reference-Cited by-同舟云学术

Discovery of (2S)-N-[(1R)-2-[4-cyclohexyl-4-[[(1,1-dimethylethyl)amino]carbonyl]-1-piperidinyl]-1-[(4-fluorophenyl)methyl]-2-oxoethyl]-4-methyl-2-piperazinecarboxamide (MB243), a potent and selective melanocortin subtype-4 receptor agonist

Published:2005-01 Issue:1 Volume:15 Page:171-175
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Palucki Brenda L.,Park Min K.,Nargund Ravi P.,Ye Zhixiong,Sebhat Iyassu K.,Pollard Patrick G.,Kalyani Rubana N.,Tang Rui,MacNeil Tanya,Weinberg David H.,Vongs Aurawan,Rosenblum Charles I.,Doss George A.,Miller Randall R.,Stearns Ralph A.,Peng Qianping,Tamvakopoulos Constantin,McGowan Erin,Martin William J.,Metzger Joseph M.,Shepherd Cherrie A.,Strack Alison M.,MacIntyre D. Euan,Van der Ploeg Lex H.T.,Patchett Arthur A.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference40 articles.

1. Melanocortin Receptors and Erectile Function

2. Melanocortin ligands: 30 years of structure-activity relationship (SAR) studies

3. Melanocortins and their Receptors and Antagonists

4. Chapter 4. Melanocortin-4 receptor agonists and antagonists: Chemistry and potential therapeutic utilities

5. The melanocortin system

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