A calcineurin antifungal strategy with analogs of FK506-Reference-Cited by-同舟云学术

A calcineurin antifungal strategy with analogs of FK506

Published:2017-06 Issue:11 Volume:27 Page:2465-2471
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Nambu Mitchell,Covel Jonathan A.,Kapoor Mili,Li Xiaoming,Moloney Molly K.,Numa Mehdi M.,Soltow Quinlyn A.,Trzoss Michael,Webb Peter,Webb Robert R.,Mutz Mitchell

Funder

NIH

NIAID

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

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3. Immunosuppressive and nonimmunosuppressive cyclosporine analogs are toxic to the opportunistic fungal pathogen cryptococcus neoformans via cyclophilin-dependent inhibition of calcineurin;Cruz;Antimicrob Agents Chemother,2000

4. Harnessing calcineurin as a novel anti-infective agent against invasive fungal infections;Steinbach;Nat Rev,2007

5. Calcineurin is required for virulence of Cryptococcus neoformans;Odom;EMBO J,1997

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