Lead generation of heat shock protein 90 inhibitors by a combination of fragment-based approach, virtual screening, and structure-based drug design-Reference-Cited by-同舟云学术

Lead generation of heat shock protein 90 inhibitors by a combination of fragment-based approach, virtual screening, and structure-based drug design

Published:2011-10 Issue:19 Volume:21 Page:5778-5783
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Miura Takaaki,Fukami Takaaki A.,Hasegawa Kiyoshi,Ono Naomi,Suda Atsushi,Shindo Hidetoshi,Yoon Dong-Oh,Kim Sung-Jin,Na Young-Jun,Aoki Yuko,Shimma Nobuo,Tsukuda Takuo,Shiratori Yasuhiko

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference17 articles.

1. Hsp90 inhibition: Elimination of shock and stress

2. Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation.

3. Targeting Hsp90: small-molecule inhibitors and their clinical development

4. Discovery and development of Hsp90 inhibitors: a promising pathway for cancer therapy

5. Fragment-Based Drug Discovery Applied to Hsp90. Discovery of Two Lead Series with High Ligand Efficiency

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