A comparative study of warheads for design of cysteine protease inhibitors

Author:

Silva Daniel G.,Ribeiro Jean F.R.,De Vita Daniela,Cianni Lorenzo,Franco Caio Haddad,Freitas-Junior Lucio H.,Moraes Carolina Borsoi,Rocha Josmar R.,Burtoloso Antonio C.B.,Kenny Peter W.,Leitão Andrei,Montanari Carlos A.

Funder

Fundação de Amparo à Pesquisa do Estado de São Paulo

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference29 articles.

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2. Cysteine cathepsin proteases as pharmacological targets in cancer;Palermo;Trends Pharm Sci.,2008

3. The discovery of odanacatib (MK-0822), a selective inhibitor of cathepsin K;Gauthier;Bioorg Med Chem Lett,2008

4. A macrocyclic calpain inhibitor slows the development of inherited cortical cataracts in a sheep model;Morton;Invest Ophthalmol Vis Sci,2013

5. Cruzipain, the major cysteine proteinase from the protozoan parasite Trypanosoma cruzi;Cazzulo;Biol Chem,1997

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