Evaluating the druggability of TrmD, a potential antibacterial target, through design and microbiological profiling of a series of potent TrmD inhibitors

Author:

Wilkinson Andrew J.ORCID,Ooi Nicola,Finlayson Jonathan,Lee Victoria E.ORCID,Lyth David,Maskew Kathryn S.,Newman Rebecca,Orr David,Ansell Keith,Birchall Kristian,Canning PeterORCID,Coombs PeterORCID,Fusani Lucia,McIver Ed,Pisco JoãoORCID,Ireland Philip M.,Jenkins Christopher,Norville Isobel H.,Southern Stephanie J.,Cowan RichardORCID,Hall Gareth,Kettleborough Catherine,Savage Victoria J.ORCID,Cooper Ian R.ORCID

Funder

United Kingdom Ministry of Defence

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference29 articles.

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2. WHO publishes list of bacteria for which new antibiotics are urgently needed. Published February 27, 2017. Accessed June 29, 2022. https://www.who.int/news/item/27-02-2017-who-publishes-list-of-bacteria-for-which-new-antibiotics-are-urgently-needed.

3. Chromosomal location and cloning of the gene (trmD) responsible for the synthesis of tRNA (m1G) methyltransferase in Escherichia coli K-12;Byström;Mol Gen Genet,1982

4. Experimental determination and system level analysis of essential genes in Escherichia coli MG1655;Gerdes;J Bacteriol,2003

5. Identification of 113 conserved essential genes using a high-throughput gene disruption system in Streptococcus pneumoniae;Thanassi;Nucleic Acids Res,2002

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