Optimization of a 1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione series of HIV capsid assembly inhibitors 2: Structure–activity relationships (SAR) of the C3-phenyl moiety

Author:

Fader Lee D.,Landry Serge,Goulet Sylvie,Morin Sébastien,Kawai Stephen H.,Bousquet Yves,Dion Isabelle,Hucke Oliver,Goudreau Nathalie,Lemke Christopher T.,Rancourt Jean,Bonneau Pierre,Titolo Steve,Amad Ma’an,Garneau Michel,Duan Jianmin,Mason Stephen,Simoneau Bruno

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference17 articles.

1. UNAIDS Report on the Global Aids Epidemic, 2012. Available online at: http://www.unaids.org/en/media/unaids/contentassets/documents/epidemiology/2012/gr2012/20121120_UNAIDS_Global_Report_2012_en.pdf (Accessed: December 5, 2012).

2. Novel approaches to inhibiting HIV-1 replication

3. Optimization of a 1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione series of HIV capsid assembly inhibitors 1: Addressing configurational instability through scaffold modification

4. Discovery of a 1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione series of inhibitors of HIV-1 capsid assembly

5. Detailed experimental procedures for most of the compounds in the present manuscript can be found in: Simoneau, B.; Deroy, P.; Fader, L.; Faucher, A.-M.; Gagnon, A.; Grand-Maitre, C.; Kawai, S.; Landry, S.; Mercier, J.-F.; Rancourt, J. PCT Int. Appl. WO 2011/100838.

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