Synthesis and structure–activity relationships of a novel and selective bone morphogenetic protein receptor (BMP) inhibitor derived from the pyrazolo[1.5-a]pyrimidine scaffold of Dorsomorphin: The discovery of ML347 as an ALK2 versus ALK3 selective MLPCN probe-Reference-Cited by-同舟云学术

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Synthesis and structure–activity relationships of a novel and selective bone morphogenetic protein receptor (BMP) inhibitor derived from the pyrazolo[1.5-a]pyrimidine scaffold of Dorsomorphin: The discovery of ML347 as an ALK2 versus ALK3 selective MLPCN probe

Published:2013-06 Issue:11 Volume:23 Page:3248-3252
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Engers Darren W.,Frist Audrey Y.,Lindsley Craig W.,Hong Charles C.,Hopkins Corey R.

Funder

NIH/MLPCN

NIH

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference22 articles.

1. Applications of small molecule BMP inhibitors in physiology and disease

2. SPECIFICITY AND VERSATILITY IN TGF-β SIGNALING THROUGH SMADS

3. Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism

4. Perturbation of hepcidin expression by BMP type I receptor deletion induces iron overload in mice

5. Inhibition of bone morphogenetic protein signaling attenuates anemia associated with inflammation

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