Discovery of N-[(1-aryl-1H-indazol-5-yl)methyl]amides derivatives as smoothened antagonists for inhibition of the hedgehog pathway-Reference-Cited by-同舟云学术

Discovery of N-[(1-aryl-1H-indazol-5-yl)methyl]amides derivatives as smoothened antagonists for inhibition of the hedgehog pathway

Published:2009-08 Issue:15 Volume:19 Page:4191-4195
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Dessole Gabriella,Branca Danila,Ferrigno Federica,Kinzel Olaf,Muraglia Ester,Palumbi Maria Cecilia,Rowley Michael,Serafini Sergio,Steinkühler Christian,Jones Philip

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference16 articles.

1. Hedgehog Signaling in Development and Cancer

2. Targeting the Hedgehog pathway in cancer

3. Hedgehog signalling in cancer formation and maintenance

4. Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function

5. Mutations in the human Sonic Hedgehog gene cause holoprosencephaly

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