A novel series of positive modulators of the AMPA receptor: Structure-based lead optimization-Reference-Cited by-同舟云学术

A novel series of positive modulators of the AMPA receptor: Structure-based lead optimization

Published:2010-10 Issue:20 Volume:20 Page:6072-6075
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Jamieson Craig,Campbell Robert A.,Cumming Iain A.,Gillen Kevin J.,Gillespie Jonathan,Kazemier Bert,Kiczun Michael,Lamont Yvonne,Lyons Amanda J.,Maclean John K.F.,Martin Frederic,Moir Elizabeth M.,Morrow John A.,Pantling John,Rankovic Zoran,Smith Lynn

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference7 articles.

1. Structure of a glutamate-receptor ligand-binding core in complex with kainate

2. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

3. Drug-like properties and the causes of poor solubility and poor permeability

4. Selectivity profiling against a panel of 80 receptors and channels carried out by Caliper Life Sciences, 68 Elm Street, Hopkinton, MA 01748 USA; www.caliperls.com.

5. Potentiation of responses to AMPA on central neurones by LY392098 and LY404187 in vivo

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