Discovery of 7-(3-(piperazin-1-yl)phenyl)pyrrolo[2,1-f][1,2,4]triazin-4-amine derivatives as highly potent and selective PI3Kδ inhibitors-Reference-Cited by-同舟云学术

Discovery of 7-(3-(piperazin-1-yl)phenyl)pyrrolo[2,1-f][1,2,4]triazin-4-amine derivatives as highly potent and selective PI3Kδ inhibitors

Published:2017-02 Issue:4 Volume:27 Page:855-861
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Qin Lan-Ying,Ruan Zheming,Cherney Robert J.,Dhar T.G. Murali,Neels James,Weigelt Carolyn A.,Sack John S.,Srivastava Anurag S.,Cornelius Lyndon A.M.,Tino Joseph A.,Stefanski Kevin,Gu Xiaomei,Xie Jenny,Susulic Vojkan,Yang Xiaoxia,Yarde-Chinn Melissa,Skala Stacey,Bosnius Ruth,Goldstein Christine,Davies Paul,Ruepp Stefan,Salter-Cid Luisa,Bhide Rajeev S.,Poss Michael A.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference34 articles.

1. The emerging mechanisms of isoform-specific PI3K signalling

2. The Phosphoinositide 3-Kinase Pathway

3. Signalling through Class I PI3Ks in mammalian cells

4. Genetic predisposition to autoimmunity – What have we learned?

5. PI3Kδ and PI3Kγ: partners in crime in inflammation in rheumatoid arthritis and beyond?

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