Optimization of a series of potent, selective and orally bioavailable SYK inhibitors
Author:
Publisher
Elsevier BV
Subject
Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry
Reference28 articles.
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3. SYK as a new therapeutic target in B-cell precursor acute lymphoblastic leukemia;Uckun;J Cancer Ther,2014
4. Molecular cloning of human Syk. A B cell protein-tyrosine kinase associated with the surface immunoglobulin M-B cell receptor complex;Law;J Biol Chem,1994
5. The structure and function of nonreceptor tyrosine kinase p72syk expressed in hematopoietic cells;Yanagi;Cell Signal,1995
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1. Optimization of a series of novel, potent and selective Macrocyclic SYK inhibitors;Bioorganic & Medicinal Chemistry Letters;2023-07
2. Impact of Interindividual Differences in Plasma Fraction Unbound on the Pharmacokinetics of a Novel Syk Kinase Inhibitor in Beagle Dogs;Drug Metabolism and Disposition;2021-06-16
3. Novel potent and selective pyrazolylpyrimidine-based SYK inhibitors;Bioorganic & Medicinal Chemistry Letters;2020-11
4. SYK Inhibitor with Improved hERG-Profile;Synfacts;2020-09-17
5. Identification of a novel series of azabenzimidazole-derived inhibitors of spleen tyrosine kinase;Bioorganic & Medicinal Chemistry Letters;2020-09
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